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In vitro efficacy of disinfectants utilised for skin decolonisation and environmental decontamination during a hospital outbreak with Candida auris
Author(s) -
Abdolrasouli Alireza,
ArmstrongJames Darius,
Ryan Lisa,
Schelenz Silke
Publication year - 2017
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12699
Subject(s) - candida auris , chlorhexidine , antiseptic , microbiology and biotechnology , chlorine , disinfectant , human decontamination , medicine , hydrogen peroxide , chlorine dioxide , chemistry , biology , antifungal , organic chemistry , dentistry , pathology
Summary Candida auris has caused nosocomial infections and transmissions within hospital settings. As little is known about the efficacy of skin and environmental decontamination products to kill C. auris , this study investigated the in vitro activity of chlorine, chlorhexidine, iodine povidone and vaporised hydrogen peroxide products against C. auris . H 2 O 2 vapour showed 96.6%‐100% effective killing of C. auris . All isolates were inhibited by chlorhexidine gluconate concentrations at 0.125%‐1.5% and for iodinated povidone at 0.07%‐1.25%. Other species of Candida were also killed at 1000 ppm chlorine except C. parapsilosis which failed to be killed at 3 minutes contact time. We conclude that chlorhexidine gluconate, iodinated povidone, chlorine and H 2 O 2 vapour demonstrate effective killing activity against C. auris at concentrations used in clinical practice.