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Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia
Author(s) -
Rizzello Ilaria,
Castagnetti Fausto,
Toschi Pier Giorgio,
Bertaccini Patrizia,
Primavera Laura,
Paolucci Michela,
Faccioli Luca,
Spinardi Luca,
Lewis Russell E.,
Cavo Michele,
Stanzani Marta
Publication year - 2018
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12697
Subject(s) - voriconazole , medicine , fusarium solani , posaconazole , amphotericin b , vitrectomy , endophthalmitis , fusarium , surgery , dermatology , antifungal , biology , microbiology and biotechnology , visual acuity , horticulture
Summary Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy. We also review published literature describing the management of endogenous Fusarium endophthalmitis in immunocompromised hosts.