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Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae ( Onygenales )
Author(s) -
Dukik Karolina,
Muñoz Jose F.,
Jiang Yanping,
Feng Peiying,
Sigler Lynne,
Stielow J. Benjamin,
Freeke Joanna,
Jamalian Azadeh,
Gerrits van den Ende Bert,
McEwen Juan G.,
Clay Oliver K.,
Schwartz Ilan S.,
Govender Nelesh P.,
Maphanga Tsidiso G.,
Cuomo Christina A.,
Moreno Leandro F.,
Kenyon Chris,
Borman Andrew M.,
Hoog Sybren
Publication year - 2017
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12601
Subject(s) - blastomyces dermatitidis , dimorphic fungus , biology , blastomyces , phylogenetic tree , genus , type species , zoology , blastomycosis , taxonomy (biology) , phylogenetics , evolutionary biology , yeast , genetics , gene , immunology
Summary Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast‐like phases have challenged the current taxonomy of the Ajellomycetaceae , a family currently comprising the genera Blastomyces , Emmonsia , Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides . Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia . Another novel dimorphic pathogen, producing broad‐based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces , and is described as Blastomyces percursus .