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Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases
Author(s) -
Baswan Sudhir,
Kasting Gerald B.,
Li S. Kevin,
Wickett Randy,
Adams Brian,
Eurich Sean,
Schamper Ryan
Publication year - 2017
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12592
Subject(s) - nail (fastener) , nail plate , nail disease , medicine , dermatology , materials science , paronychia , metallurgy
Summary The topical treatment of nail fungal infections has been a focal point of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. Although the current focus remains on exploring the ways of enhancing permeation through the formidable nail barrier, the understanding of the nail microstructure and composition is far from complete. This article reviews our current understanding of the nail microstructure, composition and diseases. A few of the parameters affecting the nail permeability and potential causes of the recurrence of fungal nail infection are also discussed.