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Risk factors, clinical presentation and prognosis of mixed candidaemia: a population‐based surveillance in Spain
Author(s) -
Ramos Antonio,
Romero Yolanda,
SánchezRomero Isabel,
Fortún Jesús,
Paño José Ramón,
Pemán Javier,
Gurguí Mercè,
RodríguezBaño Jesús,
Padilla Belén
Publication year - 2016
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12516
Subject(s) - medicine , incidence (geometry) , candida parapsilosis , presentation (obstetrics) , population , human immunodeficiency virus (hiv) , candida glabrata , prospective cohort study , pediatrics , antifungal , surgery , immunology , dermatology , physics , environmental health , optics
Summary The low incidence of mixed candidaemia ( MC ) may have precluded a better knowledge of its clinical presentation. The aim of the study was to analyse the risk factors, clinical presentation and prognosis of MC episodes. A comparison between MC and monomicrobial candidaemia within a prospective programme on candidaemia was performed in 29 hospitals between April 2010 and May 2011. In fifteen episodes of candidaemia corresponding to 15 patients, out of 752, two species of Candida (1.9%) were isolated. MC was more frequent in patients with HIV infection (12%, P = 0.038) and those admitted due to extensive burns (23%, P = 0.012). The Candida species most frequently identified in MC were C. albicans 12 patients (40%), C. glabrata seven patients (23.3%) and C. parapsilosis six patients (20%). Early mortality was higher (nine patients, 60%) in patients with MC than in patients with MMC (223 patients, 30.3%, P = 0.046). In conclusion, MC was was independently associated with increased mortality even after considering other prognostic factors. MC is an infrequent event that is more common in HIV infection and in patients suffering from burns, and is associated with increased mortality.