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Invasive pulmonary mycosis due to Chaetomium globosum with false‐positive galactomannan test: a case report and literature review
Author(s) -
Capoor Malini R.,
Agarwal Poojan,
Goel Manoj,
Jain Sarika,
Shivaprakash Mandya Rudramurthy,
Honnavar Prasanna,
Gupta Sunita,
Chakrabarti Arunaloke
Publication year - 2016
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12446
Subject(s) - chaetomium globosum , galactomannan , chaetomium , voriconazole , bronchoalveolar lavage , microbiology and biotechnology , medicine , pathology , aspergillus , aspergillosis , biology , lung , immunology , antifungal , botany
Summary In this case, the authors report Chaetomium globosum as a cause of invasive pulmonary infection in a patient with Wegener's granulomatosis. Fungal hyphae ( KOH and Calcofluor) were seen on direct microscopy of lung biopsy sample and bronchoalveolar lavage (BAL) sample. C. globosum isolated on culture clinched the diagnosis of invasive pulmonary infection by Chaetomium spp. A positive galactomannan of serum and BAL was repeatedly seen and was utilised for follow‐up and as prognostic marker in patient management. The patient was successfully treated with liposomal amphotericin B followed by voriconazole. All the Chaetomium infections reported till date since 1980 are reviewed. Chaetomium spp. with its unique ecology has a hidden clinical potential to cause invasive mould infections.