Premium
Utility of IgE (total and Aspergillus fumigatus specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis
Author(s) -
Agarwal Ritesh,
Aggarwal Ashutosh N.,
Sehgal Inderpaul S.,
Dhooria Sahajal,
Behera Digambar,
Chakrabarti Arunaloke
Publication year - 2016
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12423
Subject(s) - allergic bronchopulmonary aspergillosis , aspergillus fumigatus , immunoglobulin e , exacerbation , bronchiectasis , medicine , aspergillosis , immunology , allergy , lung , antibody
Summary The role of total and specific IgE in monitoring treatment responses in allergic bronchopulmonary aspergillosis ( ABPA ) remains poorly studied. Here in, we evaluate the utility of total and Aspergillus fumigatus specific IgE in the follow‐up of ABPA . Eighty‐one consecutive treatment‐naïve patients of ABPA (acute stage) with pulmonary infiltrates and bronchiectasis underwent measurement of total and A. fumigatus specific IgE at baseline, after 8 weeks of glucocorticoid therapy, and during exacerbations. There was clinical and radiological improvement after treatment with median decline of total IgE by 51.9%. The total IgE declined by at least 35%, 25% and 20% in 69 (85.2%), 76 (93.6%) and 78 (96.3%) patients, respectively. On the other hand, the A. fumigatus specific IgE increased in 42 (51.9%) subjects, and the mean increase was 1.4%, after 8 weeks. Among 13 patients with exacerbation, 12 (92.3%) had a rise of total IgE by >50%. The A. fumigatus specific IgE increased in only five (38.5%) subjects during exacerbation. Thus, the total IgE is a useful test in monitoring treatment responses in ABPA while A. fumigatus specific IgE has limited utility.