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Burden of fungal infections in Senegal
Author(s) -
Badiane Aida S.,
Ndiaye Daouda,
Denning David W.
Publication year - 2015
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12381
Subject(s) - medicine , fungal keratitis , epidemiology , incidence (geometry) , allergic bronchopulmonary aspergillosis , esophageal candidiasis , cryptococcosis , aspergillosis , tuberculosis , dermatology , mycosis , case fatality rate , pneumonia , prevalence , immunology , human immunodeficiency virus (hiv) , pathology , viral disease , keratitis , physics , immunoglobulin e , antibody , optics
Summary Senegal has a high rate of tuberculosis and a low HIV seropositivity rate and aspergilloma, life‐threatening fungal infections, dermatophytosis and mycetoma have been reported in this study. All published epidemiology papers reporting fungal infection rates from Senegal were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in each to estimate national incidence or prevalence. The results show that tinea capitis is common being found in 25% of children, ~1.5 million. About 191 000 Senegalese women get recurrent vaginal thrush, ≥4 times annually. We estimate 685 incident cases of chronic pulmonary aspergillosis ( CPA ) following TB and prevalence of 2160 cases. Asthma prevalence in adults varies from 3.2% to 8.2% (mean 5%); 9976 adults have allergic bronchopulmonary aspergillosis ( ABPA ) and 13 168 have severe asthma with fungal sensitisation ( SAFS ). Of the 59 000 estimated HIV ‐positive patients, 366 develop cryptococcal meningitis; 1149 develop Pneumocystis pneumonia and 1946 develop oesophageal candidiasis, in which oral candidiasis (53%) and dermatophytosis (16%) are common. Since 2008–2010, 113 cases of mycetoma were diagnosed. In conclusion, we estimate that 1 743 507 (12.5%) people in Senegal suffer from a fungal infection, excluding oral candidiasis, fungal keratitis, invasive candidiasis or aspergillosis. Diagnostic and treatment deficiencies should be rectified to allow epidemiological studies.