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Treatment of neonatal fungal infective endocarditis with recombinant tissue plasminogen: activator in a low birth weight infant case report and review of the literature
Author(s) -
Babayigit Aslan,
Cebeci Burcu,
Buyukkale Gokhan,
Yılmaz Semerci Seda,
Bornaun Helen,
Oztarhan Kazim,
Gokce Muge,
Cetinkaya Merih
Publication year - 2015
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12359
Subject(s) - medicine , endocarditis , low birth weight , sepsis , mortality rate , antibiotics , complication , antifungal , parenteral nutrition , incidence (geometry) , surgery , recombinant tissue plasminogen activator , pregnancy , pediatrics , microbiology and biotechnology , dermatology , biology , physics , ischemic stroke , optics , ischemia , modified rankin scale , genetics
Summary With advances in medical sciences, an increase in survival rates of low birth weight; increased incidence in use of catheter and antibiotics, and total parenteral nutrition are reported, therefore, the rate of fungal infections in late and very late onset neonatal sepsis have increased. Although fungal endocarditis rarely occur in newborns, it has a high morbidity and mortality. Antifungal therapy is often insufficient in cases who develop fungal endocarditis and surgical treatment is not preferred due to its difficulty and high mortality. Herein, fungal endocarditis in a preterm newborn treated with single‐dose recombinant tissue plasminogen activator in addition to antifungal therapy is presented and relevant literature has been reviewed. The vegetation completely disappeared following treatment and no complication was observed.