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In vitro susceptibility patterns of clinically important Trichophyton and Epidermophyton species against nine antifungal drugs
Author(s) -
Badali Hamid,
Mohammadi Rasoul,
Mashedi Olga,
Hoog G. Sybren,
Meis Jacques F.
Publication year - 2015
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12315
Subject(s) - posaconazole , caspofungin , terbinafine , voriconazole , anidulafungin , itraconazole , fluconazole , microbiology and biotechnology , epidermophyton floccosum , trichophyton rubrum , pharmacology , trichophyton , biology , medicine , antifungal
Summary Despite the common, worldwide, occurrence of dermatophytes, little information is available regarding susceptibility profiles against currently available and novel antifungal agents. A collection of sixty‐eight clinical Trichophyton species and Epidermophyton floccosum were previously identified and verified to the species level by sequencing the internal transcribed spacer ( ITS ) regions of rDNA . MIC s of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, terbinafine and MEC s of caspofungin and anidulafungin were performed based on CLSI M38‐A2. The resulting MIC 90 s of all strains were, in increasing order, as follows: terbinafine (0.063 mg l −1 ); posaconazole (1 mg l −1 ); isavuconazole and anidulafungin (2 mg l −1 ); itraconazole, voriconazole, amphotericin B, and caspofungin (4 mg l −1 ) and fluconazole (>64 mg l −1 ). These results confirm that terbinafine is an excellent agent for treatment of dermatophytosis due to T. rubrum, T. mentagrophytes, T. verrucosum, T. schoenleinii and E. floccosum . In addition, the new azoles POS and ISA are potentially useful antifungals to treat dermatophytosis. However, the clinical effectiveness of these novel antifungals remains to be determined.