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Pathogenesis and host defence against Mucorales: the role of cytokines and interaction with antifungal drugs
Author(s) -
Roilides Emmanuel,
Antachopoulos Charalampos,
Simitsopoulou Maria
Publication year - 2014
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12236
Subject(s) - mucorales , innate immune system , mucormycosis , biology , immune system , immunology , antifungal , immunity , pathogenesis , acquired immune system , microbiology and biotechnology , medicine , pathology
Summary Innate immune response, including macrophages, neutrophils and dendritic cells and their respective receptors, plays an important role in host defences against Mucorales with differential activity against specific fungal species, while adaptive immunity is not the first line of defence. A number of endogenous and exogenous factors, such as cytokines and growth factors as well as certain antifungal agents have been found that they influence innate immune response to these organisms. Used alone or especially in combination have been shown to exert antifungal effects against Mucorales species. These findings suggest novel ways of adjunctive therapy for patients with invasive mucormycosis.