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Regional data analysis of Candida non‐ albicans strains collected in United States medical sites over a 6‐year period, 2006–2011
Author(s) -
Pfaller Michael A.,
Jones Ronald N.,
Castanheira Mariana
Publication year - 2014
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12206
Subject(s) - anidulafungin , micafungin , candida glabrata , fluconazole , echinocandin , caspofungin , broth microdilution , microbiology and biotechnology , biology , drug resistance , candida dubliniensis , corpus albicans , candida albicans , veterinary medicine , antifungal , medicine , antimicrobial , minimum inhibitory concentration
Summary Limited data are available on temporal and geographic variation of occurrence and antifungal resistance of non‐ C. albicans Candida species (non‐ CA ‐ CSP ) from the USA . The objective of this study was to evaluate the occurrence and antifungal resistance of 1694 isolates of non‐ CA ‐ CSP collected during the period 2006–2011. Isolates were recovered in 33 hospitals located in four regions: Northcentral, North‐east, South‐east and West and tested using CLSI reference broth microdilution methods. Non‐ CA ‐ CSP represented 55.6% of all Candida . C. glabrata was most predominant (39–42% of non‐ CA ‐ CSP ). Infections due to C. glabrata, C. krusei and C. dubliniensis increased over the 6 years. Anidulafungin (3.6%) and caspofungin (5.7%) resistance were prominent among C. glabrata from the North‐east and West regions respectively. Resistance to micafungin was detected in 2.0% and 2.9% of C. glabrata from the West and North‐east regions respectively. Echinocandin resistance was low, except for C. dubliniensis . Azole resistance was most prominent among C. glabrata from the South‐east (13.6% fluconazole R) and the West (18.0%). Cross‐resistance among three tested azoles was observed in C. glabrata from all regions. Whereas differences in species distribution and antifungal R varied across geographic regions, there was little evidence of temporal increase in resistance to azoles or echinocandins in the monitored non‐ CA ‐ CSP .