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Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis
Author(s) -
Scher Richard K.,
Nakamura Norifumi,
Tavakkol Amir
Publication year - 2014
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12168
Subject(s) - antifungal , medicine , nail (fastener) , dermatology , broad spectrum , pharmacology , chemistry , materials science , combinatorial chemistry , metallurgy
Summary Luliconazole is a novel, broad‐spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro , luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.