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Evaluation of trace elements, oxidant/antioxidant status, vitamin C and β‐carotene in dogs with dermatophytosis
Author(s) -
Beigh S. A.,
Soodan J. S.,
Singh R.,
Khan A. M.,
Dar M. A.
Publication year - 2014
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12163
Subject(s) - superoxide dismutase , catalase , malondialdehyde , antioxidant , microsporum gypseum , vitamin c , vitamin e , carotene , medicine , trichophyton , chemistry , biology , food science , microbiology and biotechnology , biochemistry , antifungal
Summary The aim of the study was to determine zinc, copper and iron levels, erythrocyte oxidant/antioxidant status, vitamin C and β‐carotene in dogs with dermatophytosis. A total of 23 dogs with clinically established diagnosis of dermatophytosis by trichogram and positive fungal culture and six dogs as control were included in this study. On cultural examination 52.17% fungal isolates were found to be Microsporum canis , 30.43% were Trichophyton mentagrophytes and 17.39% were M. gypseum . In comparison to healthy control, the dogs with dermatophytosis had significantly lower levels of zinc ( P < 0.01), copper ( P < 0.05), β‐carotene and vitamin C levels ( P < 0.05) and activities of superoxide dismutase ( SOD ) ( P < 0.05) and catalase ( P < 0.01), whereas the iron ( P < 0.05) and malondialdehyde ( MDA ) ( P < 0.01) levels were significantly increased. On correlation analysis, SOD activity was observed to be positively correlated ( P < 0.05) with zinc and copper in both healthy and dermatophytosis affected dogs. In dermatophytosis affected dogs the MDA levels were negatively correlated ( P < 0.05) with iron, β‐carotene levels and the activities of antioxidant enzymes; SOD and catalase. Our results demonstrated that dermatophytosis in dogs is associated with significant alteration in oxidant/antioxidant balance and trace elements. It might be secondary consequence of dermatophytosis infection or contributing factor in its pathogenesis.