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Fatal breakthrough infection with Fusarium andiyazi : new multi‐resistant aetiological agent cross‐reacting with Aspergillus galactomannan enzyme immunoassay
Author(s) -
Kebabcı Nesrin,
Diepeningen Anne D.,
Ener Beyza,
Ersal Tuba,
Meijer Martin,
AlHatmi Abdullah M.S.,
Özkocaman Vildan,
Ursavaş Ahmet,
Çetinoğlu Ezgi D.,
Akalın Halis
Publication year - 2014
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12142
Subject(s) - galactomannan , posaconazole , fusarium , biology , aspergillus , immunoassay , etiology , microbiology and biotechnology , internal transcribed spacer , immunology , aspergillosis , medicine , gene , genetics , voriconazole , antibody , ribosomal rna , antifungal
Summary Disseminated infections caused by members of the Fusarium fujikuroi species complex ( FFSC ) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC ‐ member Fusarium andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65‐year‐old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission–induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling Fusarium species, according to morphological appearance. The aetiological agent proved to be F. andiyazi based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC , but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of F. andiyazi, which had previously only been reported as a plant pathogen affecting various food crops.