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Environmental study of azole‐resistant A spergillus fumigatus with TR 34 /L98H mutations in the cyp51 A gene in I ran
Author(s) -
Badali Hamid,
Vaezi Afsane,
Haghani Iman,
Yazdanparast Seyed A.,
Hedayati Mohammad T.,
Mousavi Bita,
Ansari Saham,
Hagen Ferry,
Meis Jacques F.,
Chowdhary Anuradha
Publication year - 2013
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12089
Subject(s) - aspergillus fumigatus , azole , genotype , gene , microbiology and biotechnology , mutation , biology , antifungal , genetics
Summary Azole resistance in A spergillus is emerging in E uropean and A sian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental A spergillus fumigatus isolates in I ran. The TR 34 /L98H mutation was the only resistance mechanism. Overall 3.3% of the A . fumigatus isolates from hospital surroundings in S ari and T ehran had the same TR 34 /L98H STR Af genotype and were related to some resistant clinical and environmental TR 34 /L98H isolates from the N etherlands and I ndia. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A . fumigatus in I ran.