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Echinocandins in invasive candidiasis
Author(s) -
Simon John,
Sun HsinYun,
Leong Hoe Nam,
Barez Marie Yvette C.,
Huang PoYen,
Talwar Deepak,
Wang JenHsien,
Mansor Melor,
Wahjuprajitno Bambang,
Patel Atul,
Wittayachanyapong Siriporn,
Sany B. Shoib Mohd,
Lin ShengFong,
Dimopoulos George
Publication year - 2013
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12085
Subject(s) - echinocandins , drug , candida albicans , azole , medicine , intensive care medicine , pharmacology , amphotericin b , biology , antifungal , microbiology and biotechnology , caspofungin , dermatology
Summary We summarise a recent meeting, sponsored by Pfizer Inc., where experts in Asia shared their clinical experience in managing IC . The echinocandins have demonstrated good activity against non‐ albicans infections and also azole‐resistant strains, both preclinically and in recent clinical trials. As well as proving efficacious, echinocandins have a favourable safety profile and are well tolerated, including among inpatient subpopulations, such as transplant recipients and those with renal or hepatic dysfunction. In addition the echinocandins generally have minimal drug–drug interactions, unlike the oral azoles, which have multiple effects on cytochrome P450‐mediated drug metabolism. Echinocandins are characterised by a good safety profile, few drug–drug interactions and good susceptibilities. With the increase in potentially azole‐resistant non‐ albicans infections, echinocandins may become the first‐line treatment of choice for many patients.