Virulence of   C urvularia  in a murine model | Zendy

Paredes Katihuska | Zendy; Capilla Javier | Zendy; Sutton Deanna A. | Zendy; Mayayo Emilio | Zendy; Fothergill Annette W. | Zendy; Guarro Josep | Zendy

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Virulence of C urvularia in a murine model

Author(s) -

Paredes Katihuska,

Capilla Javier,

Sutton Deanna A.,

Mayayo Emilio,

Fothergill Annette W.,

Guarro Josep

Publication year - 2013

Publication title -

mycoses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.13

H-Index - 69

eISSN - 1439-0507

pISSN - 0933-7407

DOI - 10.1111/myc.12064

Subject(s) - virulence , histopathology , curvularia , microbiology and biotechnology , biology , lung , colony forming unit , bacteria , pathology , medicine , gene , genetics , aspergillus

Summary We have evaluated the virulence of two clinically relevant species of C urvularia ; C urvularia spicifera and C . hawaiiensis, using an experimental model of disseminated infection in immunocompromised mice. Several inocula were tested over a range 1 × 10 3 –1 × 10 6 colony‐forming units/animal. Both species had a similar behaviour, producing a high mortality. Tissue burden and histopathology studies demonstrated that lung was the organ most affected.

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