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Virulence of C urvularia in a murine model
Author(s) -
Paredes Katihuska,
Capilla Javier,
Sutton Deanna A.,
Mayayo Emilio,
Fothergill Annette W.,
Guarro Josep
Publication year - 2013
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12064
Subject(s) - virulence , histopathology , curvularia , microbiology and biotechnology , biology , lung , colony forming unit , bacteria , pathology , medicine , gene , genetics , aspergillus
Summary We have evaluated the virulence of two clinically relevant species of C urvularia ; C urvularia spicifera and C . hawaiiensis, using an experimental model of disseminated infection in immunocompromised mice. Several inocula were tested over a range 1 × 10 3 –1 × 10 6 colony‐forming units/animal. Both species had a similar behaviour, producing a high mortality. Tissue burden and histopathology studies demonstrated that lung was the organ most affected.