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Candiduria in haematologic malignancy patients without a urinary catheter: nothing more than a frailty marker?
Author(s) -
Georgiadou Sarah P.,
Tarrand Jeffrey,
Sipsas Nikolaos V.,
Kontoyiannis Dimitrios P.
Publication year - 2013
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12024
Subject(s) - medicine , urinary system , diabetes mellitus , concomitant , candida glabrata , bacteriuria , malignancy , gastroenterology , intensive care unit , antifungal , dermatology , endocrinology
Summary There is scarcity of data regarding significance of candiduria in patients with haematologic malignancies and its association with invasive candidiasis. To that end, we retrospectively evaluated all hospitalised, non‐intensive care unit patients with haematologic malignancies and candiduria during a 10‐year period (2001–2011). To decrease the possibility of bladder colonisation and sample contamination, we excluded all patients with candiduria who had urinary catheters and those with concomitant bacteriuria. Twenty‐four such patients (21 females) were identified, with median age at diagnosis 62 years (range, 20–82 years). Acute leukaemia was the most common underlying disease (54%); 62% of these cases were not in remission. Twenty‐nine percent of the patients had diabetes mellitus and 25% were neutropenic. The most common isolated Candida species was Candida glabrata (37%), followed by C. albicans (29%). Only 8% of them had urinary tract infection symptoms. However, 88% received systemic antifungals. Candidemia and crude mortality rates at 4 weeks were low (4% and 12% respectively). Isolated candiduria in patients with haematologic malignancies has risk factors similar to those in other hospitalised patients, and it does not seem to be a strong predictor of subsequent invasive candidiasis.