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Important aspects of oral paracoccidioidomycosis–a literature review
Author(s) -
de Abreu e Silva Mariana Àlvares,
Salum Fernanda Gonçalves,
Figueiredo Maria Antonia,
Cherubini Karen
Publication year - 2013
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12017
Subject(s) - paracoccidioidomycosis , paracoccidioides brasiliensis , immunocompetence , dimorphic fungus , blastomycosis , disease , immune system , mycosis , medicine , oral cavity , immunology , dermatology , biology , pathology , genetics , orthodontics , yeast
Summary Paracoccidioidomycosis is a deep mycosis endemic to Latin America, with considerable morbidity and mortality. It is caused by the dimorphic fungus Paracoccidioides brasiliensis , which affects, among other organs in the human body, the oral cavity. Fungus virulence and immunocompetence of the host determine the establishment of infection or active disease, whose severity and clinical behaviour depend mostly on the cellular immune response of the host. Often, oral lesions constitute the first sign and site of confirmation of diagnosis, which in most cases is delayed. The success of the treatment depends on early and correct diagnosis, as well as on the patient’s adherence to the drug therapy.