Open AccessThe eukaryotic protein kinase superfamily of the necrotrophic fungal plant pathogen, S clerotinia sclerotiorum
Author(s) -
Hegedus Dwayne D.,
Gerbrandt Kelsey,
Coutu Cathy
Publication year - 2016
Publication title -
molecular plant pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 103
eISSN - 1364-3703
pISSN - 1464-6722
DOI - 10.1111/mpp.12321
Subject(s) - sclerotinia sclerotiorum , biology , gene , kinase , mycelium , pathogen , genome , genetics , protein domain , computational biology , microbiology and biotechnology , botany
Summary Protein kinases have been implicated in the regulation of many processes that guide pathogen development throughout the course of infection. A survey of the S clerotinia sclerotiorum genome for genes encoding proteins containing the highly conserved eukaryotic protein kinase (e PK ) domain, the largest protein kinase superfamily, revealed 92 S . sclerotiorum e PK s. This review examines the composition of the S . sclerotiorum ePKs based on conserved motifs within the e PK domain family, and relates this to orthologues found in other filamentous fungi and yeasts. The ePKs are also discussed in terms of their proposed role(s) in aspects of host pathogenesis, including the coordination of mycelial growth/development and deployment of pathogenicity determinants in response to environmental stimuli, nutrients and stress.