Premium
Signaling pathways involved in environmental sensing in Trypanosoma cruzi
Author(s) -
Lander Noelia,
Chiurillo Miguel A.,
Docampo Roberto
Publication year - 2021
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/mmi.14621
Subject(s) - biology , trypanosoma cruzi , signal transduction , microbiology and biotechnology , immune system , second messenger system , intracellular , adaptation (eye) , oxidative stress , function (biology) , chagas disease , parasite hosting , immunology , biochemistry , neuroscience , world wide web , computer science
Trypanosoma cruzi is a unicellular parasite and the etiologic agent of Chagas disease. The parasite has a digenetic life cycle alternating between mammalian and insect hosts, where it faces a variety of environmental conditions to which it must adapt in order to survive. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Major environmental changes include temperature, nutrient availability, ionic composition, pH, osmolarity, oxidative stress, contact with host cells and tissues, host immune response, and intracellular life. Some of the signaling pathways and second messengers potentially involved in the response to these changes have been elucidated in recent years and will be the subject of this review.