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Keeping replication on par with division in Bacillus
Author(s) -
Haeusser Daniel P.,
Levin Petra A.
Publication year - 2019
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/mmi.14338
Subject(s) - biology , bacillus subtilis , nucleoid , cell division , division (mathematics) , dna replication , chromosome segregation , selection (genetic algorithm) , microbiology and biotechnology , genetics , computational biology , bacteria , chromosome , dna , gene , escherichia coli , cell , arithmetic , mathematics , artificial intelligence , computer science
Summary Spatially, division site selection is one of the most precisely controlled processes in bacterial physiology. Despite its obvious importance to the production of properly sized, viable daughter cells, the mechanisms underlying division site selection have remained largely mysterious. Molecular Microbiology , Hajduk et al . provide new insight into this essential process. Overturning previous models, including one of their own, they discover that two factors involved in chromosome remodeling – the ParB‐like protein Spo0J, and the nucleoid‐associated protein Noc – work together to coordinate early steps in DNA replication with establishment of a medial division site in the Gram‐positive bacterium, Bacillus subtilis.