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To ∼ P or Not to ∼ P ? Non‐canonical activation by two‐component response regulators
Author(s) -
Desai Stuti K.,
Kenney Linda J.
Publication year - 2017
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/mmi.13532
Subject(s) - biology , response regulator , regulator , phosphorylation , microbiology and biotechnology , two component regulatory system , kinase , component (thermodynamics) , organism , computational biology , signalling , genetics , bacteria , bacterial protein , gene , mutant , physics , thermodynamics
Summary Bacteria sense and respond to their environment through the use of two‐component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two‐component systems an organism possesses. Recent advances in this area have identified numerous variations on the archetype systems that employ a sensor kinase and a response regulator. It is now evident that many orphan regulators that lack cognate kinases do not rely on phosphorylation for activation and new roles for unphosphorylated response regulators have been identified. The significance of recent findings and suggestions for further research are discussed.