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Benzamides are potent FtsZ inhibitors and lead compounds for antibiotic development. A complex of Staphylococcus aureus FtsZ bound to the benzamide PC190723 (PC) and GDP (PDB 3VOB) is shown with amino acid substitutions that lead to PC‐resistance (orange) and PC‐dependence (red) highlighted. For details, see the article by Adams et al . on pp. 1028–1042 of this issue.
Publication year - 2016
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/mmi.13180
Subject(s) - ftsz , benzamide , staphylococcus aureus , biology , protein data bank (rcsb pdb) , biochemistry , stereochemistry , bacteria , genetics , bacterial protein , chemistry