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In Bacteria, the replicative DNA ligase is NAD‐dependent. However, some bacteria possess accessory ATP‐dependent DNA ligases (ADLs) which vary in size and domain organization. Phylogenomic analyses of bacterial ADLs reveal that types Lig B, Lig C and Lig D have descended from a common ancestor, while Lig E was transferred in a separate event, possibly from a bacteriophage. For details, see the article by Williamson et al . on pp. 274‐290 of this issue.
Publication year - 2016
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/mmi.13176
Subject(s) - biology , dna ligase , dna ligases , bacteria , dna , genetics , nad+ kinase , computational biology , enzyme , biochemistry