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Summary  Differential regulation of transcript stability is an effective means by which an organism can modulate gene expression. A well‐characterized example is glutamine signalled degradation of specific transcripts in   A spergillus nidulans . In the case of   areA  , which encodes a wide‐domain transcription factor mediating nitrogen metabolite repression, the signal is mediated through a highly conserved region of the 3′  UTR . Utilizing this  RNA  sequence we isolated  RrmA , an  RNA  recognition motif protein. Disruption of the respective gene led to loss of both glutamine signalled transcript degradation as well as nitrate signalled stabilization of   niaD   m RNA . However, nitrogen starvation was shown to act independently of  RrmA  in stabilizing certain transcripts.  RrmA  was also implicated in the regulation of arginine catabolism gene expression and the oxidative stress responses at the level of m RN A stability. Δ  rrmA   mutants are hypersensitive to oxidative stress. This phenotype correlates with destabilization of   eifE   and   dhsA   m RNA .   eifE   encodes  eIF5A , a translation factor within which a conserved lysine is post‐translationally modified to hypusine, a process requiring  DhsA . Intriguingly, for specific transcripts  RrmA  mediates both stabilization and destabilization and the specificity of the signals transduced is transcript dependent, suggesting it acts in consort with other factors which differ between transcripts.

RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress