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Studies on the Neutralizing Antibody to Herpes Simplex Virus
Author(s) -
OHASHI Masami,
OZAKI Yoshikatsu
Publication year - 1982
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/mim.1982.26.7.569
Subject(s) - antibody , herpes simplex virus , virology , neutralizing antibody , biology , antibody titer , titer , virus , immunology
The type‐specific antibody responses in rabbits immunized with both types of herpes simplex virus (HSV), measured by complement‐requiring neutralizing (CRN) and slow‐reacting CRN (s‐CRN) antibody assays were compared. Titers of type‐specific antibody measured by s‐CRN antibody assay were always markedly higher than those measured by CRN antibody assay. The s‐CRN antibody assay was so sensitive that even an undetectable level of CRN antibody could be readily detected by this method. The detection of type‐specific antibody by s‐CRN antibody assay may be useful when attempting to analyze human HSV infection.