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Effect of orthostasis on the regulation of skin blood flow in upper and lower extremities in human
Author(s) -
Tikhonova Irina V.,
Grinevich Andrey A.,
Guseva Irina E.,
Tankanag Arina V.
Publication year - 2021
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12655
Subject(s) - forearm , blood flow , respiration , heart rate , medicine , cardiology , hemodynamics , anesthesia , blood pressure , anatomy
Objective The research is aimed to investigate interactions between cardiovascular signals and to assess contributions of central and local mechanisms to skin blood flow regulation in upper and lower extremities at rest and under orthostasis. Methods Heart rate variability, respiration, forearm, and foot skin blood flow were assessed at rest and during postural test in 25 healthy volunteers. Spectral analysis was performed. Phase synchronization degree of analyzed signals was determined by group phase wavelet coherence function. Results Skin blood flow was lower on foot at rest and during postural test than on forearm. High‐frequency component of heart rate variability was higher at ~0.3 Hz during postural test versus rest. Blood flow oscillation amplitudes on the foot were lower in frequency range including respiratory interval at rest than on forearm. Postural exposure increased amplitude of foot blood flow oscillations in respiratory interval and decreased amplitudes in cardiac interval versus rest. Orthostasis increased group wavelet phase coherence between foot blood flow and heart rate variability or respiration, as well as between forearm and foot blood flow at 0.3 Hz corresponding to respiration. Conclusions The contribution of central mechanisms associated with respiration to blood flow regulation increased in lower extremities during orthostasis.