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Early retinal microvascular abnormalities in patients with chronic kidney disease
Author(s) -
Yeung Ling,
Wu IWen,
Sun ChiChin,
Liu ChunFu,
Chen ShinYi,
Tseng ChungHsin,
Lee HsinChin,
Lee ChinChan
Publication year - 2019
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12555
Subject(s) - medicine , kidney disease , retinal , diabetes mellitus , renal function , cardiology , retina , ophthalmology , endocrinology , physics , optics
Objective To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease ( CKD ) via optical coherence tomography angiography. Methods A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus ( SVP ) and deep vascular plexus ( DVP ) between the CKD and control groups. Results The mean ages were 62.7 ± 10.1 in the CKD group and 61.9 ± 9.7 ( P = 0.622) in the control group. The CKD group had reduced parafoveal vessel densities in SVP (46.7 ± 4.3 vs 49.7 ± 2.9, P < 0.001) and DVP (50.1 ± 4.1 vs 52. 6 ± 2.9, P < 0.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti‐hypertensive drugs were factors associated with vessel density in SVP , whereas age, diabetes, and smoking were factors associated with vessel density in DVP . Conclusion Patients with CKD had reduced vessel densities in parafoveal SVP and DVP , as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors.