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Fractal characterization of retinal microvascular network morphology during diabetic retinopathy progression
Author(s) -
Popovic Natasa,
Lipovac Mirko,
Radunovic Miroslav,
Ugarte Jurgi,
Isusquiza Erik,
Beristain Andoni,
Moreno Ramón,
Aranjuelo Nerea,
Popovic Tomo
Publication year - 2019
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12531
Subject(s) - retinal , diabetic retinopathy , lacunarity , segmentation , box counting , fractal dimension , ophthalmology , fundus (uterus) , medicine , fractal analysis , fractal , artificial intelligence , computer science , pattern recognition (psychology) , diabetes mellitus , mathematics , endocrinology , mathematical analysis
Objective The study aimed to characterize morphological changes of the retinal microvascular network during the progression of diabetic retinopathy. Methods Publicly available retinal images captured by a digital fundus camera from DIARETDB 1 and STARE databases were used. The retinal microvessels were segmented using the automatic method, and vascular network morphology was analyzed by fractal parametrization such as box‐counting dimension, lacunarity, and multifractals. Results The results of the analysis were affected by the ability of the segmentation method to include smaller vessels with more branching generations. In cases where the segmentation was more detailed and included a higher number of vessel branching generations, increased severity of diabetic retinopathy was associated with increased complexity of microvascular network as measured by box‐counting and multifractal dimensions, and decreased gappiness of retinal microvascular network as measured by lacunarity parameter. This association was not observed if the segmentation method included only 3‐4 vessel branching generations. Conclusions Severe stages of diabetic retinopathy could be detected noninvasively by using high resolution fundus photography and automatic microvascular segmentation to the high number of branching generations, followed by fractal analysis parametrization. This approach could improve risk stratification for the development of microvascular complications, cardiovascular disease, and dementia in diabetes.