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Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall
Author(s) -
Gorshkov Alexander Y.,
Klimushina Marina V.,
Boytsov Sergei A.,
Kots Alexander Y.,
Gumanova Nadezhda G.
Publication year - 2018
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12454
Subject(s) - microcirculation , medicine , cardiology , blood flow , glycocalyx , laser doppler velocimetry , blood pressure , pathology , immunology
Objective PBR characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation and other vascular parameters. The goal of our study was to reliably quantify PBR and assess its potential use as a new marker of cardiovascular pathology. Methods The study included 208 patients (123 men and 85 women from 40 to 65 years of age) with various grades of cardiovascular SCORE risk index and IHD. PBR was quantified by sidestream dark field capillaroscopy with green light excitation. Cutaneous microcirculation was evaluated with laser Doppler fluorometry. Results Elevated PBR values over 2 mm were associated with morphological and functional lesions of arterial wall and microcirculation and lowered levels of ApoA1 lipoprotein. Moreover, elevated PBR values were associated with 2.07‐fold increase in prevalence of cerebral atherosclerosis ( P = .015) and 2.42‐fold increase in prevalence of IHD ( P = .024). Increase in PBR was associated with elevated systolic blood pressure. Conclusions Thus, PBR can be considered a new highly reproducible and promising marker candidate for non‐invasive diagnostics of IHD and cerebral atherosclerosis suggesting important role of microcirculation in development and progression of cardiovascular diseases.