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The relationship between forearm skin speed‐resolved perfusion and oxygen saturation, and finger arterial pulsation amplitudes, as indirect measures of endothelial function
Author(s) -
Bergstrand Sara,
Morales MariaAurora,
Coppini Giuseppe,
Larsson Marcus,
Strömberg Tomas
Publication year - 2018
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12422
Subject(s) - reactive hyperemia , forearm , perfusion , microcirculation , blood flow , medicine , oxygen saturation , oxygenation , occlusion , peripheral , cardiology , oxygen , biomedical engineering , anatomy , chemistry , organic chemistry
Objective Endothelial function is important for regulating peripheral blood flow to meet varying metabolic demands and can be measured indirectly during vascular provocations. In this study, we compared the PAT finger response (Endo PAT ) after a 5‐minutes arterial occlusion to that from forearm skin comprehensive microcirculation analysis ( EPOS ). Methods Measurements in 16 subjects with varying cardiovascular risk factors were carried out concurrently with both methods during arterial occlusion, while forearm skin was also evaluated during local heating. Results Peak values for EPOS skin Perf conv and speed‐resolved total perfusion after the release of the occlusion were significantly correlated to the Endo PAT RHI (ρ = .68, P = .007 and ρ = .60, P = .025, respectively), mainly due to high‐speed blood flow. During local heating, EPOS skin oxygen saturation, S O 2 , was significantly correlated to RHI (ρ = .62, P = .043). This indicates that S O 2may have diagnostic value regarding endothelial function. Conclusions We have demonstrated for the first time a significant relationship between forearm skin microcirculatory perfusion and oxygen saturation and finger PAT. Both local heating and reactive hyperemia are useful skin provocations. Further studies are needed to understand the precise regulation mechanisms of blood flow and oxygenation during these tests.