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Muscle microcirculation alterations and relation to dipping status in newly diagnosed untreated patients with arterial hypertension—A pilot study
Author(s) -
Tzanis Georgios,
Dimopoulos Stavros,
Manetos Chris,
Koroboki Eleni,
Manios Efstathios,
Vasileiadis Ioannis,
Zakopoulos Nikolaos,
Nanas Serafim
Publication year - 2017
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12384
Subject(s) - microcirculation , medicine , skeletal muscle , cardiology , vascular occlusion
Objective The importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with NIRS , a noninvasive method that evaluates microcirculation. Methods We evaluated 34 subjects, 17 patients with AH (13 males, 49±13 years, BMI : 26±2 kg/m 2 ) and 17 healthy controls (12 males, 49±15 years, BMI : 25±3 kg/m 2 ). The thenar muscle StO 2 (%) was measured by NIRS before, during and after 3‐minutes vascular occlusion to calculate OCR (%/min), EF (%/min), and RHT (minute). The dipping status of hypertensive patients was assessed. Results The RHT differed between AH patients and healthy subjects (2.6±0.3 vs 2.1±0.3 minutes, P <.001). Dippers had higher EF than nondippers (939±280 vs 710±164%/min, P =.05). Conclusions The study suggests an impaired muscle microcirculation in newly diagnosed, untreated AH patients.