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Tissue‐engineered 3D microvessel and capillary network models for the study of vascular phenomena
Author(s) -
Bogorad Max I.,
DeStefano Jackson,
Wong Andrew D.,
Searson Peter C.
Publication year - 2017
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12360
Subject(s) - microvessel , vascular network , capillary action , chemistry , biomedical engineering , computer science , anatomy , pathology , biology , medicine , materials science , immunohistochemistry , composite material
Advances in tissue engineering, cell biology, microfabrication, and microfluidics have led to the development of a wide range of vascular models. Here, we review platforms based on templated microvessel fabrication to generate increasingly complex vascular models of (i) the tumor microenvironment, (ii) occluded microvessels, and (iii) perfused capillary networks. We outline fabrication guidelines and demonstrate a number of experimental methods for probing vascular function such as permeability measurements, tumor cell intravasation, flow characterization, and endothelial cell morphology and proliferation.