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Mesenchymal stem cells and vascular regeneration
Author(s) -
Gu Wenduo,
Hong Xuechong,
Potter Claire,
Qu Aijuan,
Xu Qingbo
Publication year - 2017
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12324
Subject(s) - mesenchymal stem cell , regeneration (biology) , regenerative medicine , cell therapy , angiogenesis , medicine , stem cell , cell type , therapeutic angiogenesis , stem cell therapy , immunology , bioinformatics , cancer research , cell , biology , microbiology and biotechnology , pathology , neovascularization , genetics
In recent years, MSC s have emerged as a promising therapeutic cell type in regenerative medicine. They hold great promise for treating cardiovascular diseases, such as myocardial infarction and limb ischemia. MSC s may be utilized in both cell‐based therapy and vascular graft engineering to restore vascular function, thereby providing therapeutic benefits to patients. The efficacy of MSC s lies in their multipotent differentiation ability toward vascular smooth muscle cells, endothelial cells and other cell types, as well as their capacity to secrete various trophic factors, which are potent in promoting angiogenesis, inhibiting apoptosis and modulating immunoreaction. Increasing our understanding of the mechanisms of MSC involvement in vascular regeneration will be beneficial in boosting present therapeutic approaches and developing novel ones to treat cardiovascular diseases. In this review, we aim to summarize current progress in characterizing the in vivo identity of MSC s, to discuss mechanisms involved in cell‐based therapy utilizing MSC s, and to explore current and future strategies for vascular regeneration.