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Treprostinil Iontophoresis Improves Digital Blood Flow during Local Cooling in Systemic Sclerosis
Author(s) -
GaillardBigot Florence,
Roustit Matthieu,
Blaise Sophie,
Cracowski Claire,
Seinturier Christophe,
Imbert Bernard,
Carpentier Patrick,
Cracowski JeanLuc
Publication year - 2016
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12272
Subject(s) - treprostinil , iontophoresis , medicine , placebo , blood flow , anesthesia , iloprost , cardiology , pulmonary hypertension , pathology , radiology , prostacyclin , alternative medicine
Severe Raynaud's syndrome and DUs are the most prevalent manifestations of SS c peripheral microvascular disease. We tested whether treprostinil iontophoresis on the finger pad of patients with SS c would improve digital blood flow during hand cooling. Methods Eleven patients with limited cutaneous SS c underwent a double‐blinded iontophoresis of treprostinil (2.56 × 10 −4 M during two hours) and placebo (NaCl 0.9%) on two finger pads. Then, the hand was inserted for 30 minutes in a fenestrated cooling box at 8°C, and skin blood flow was recorded continuously using LSCI. Results During the local cooling, CVC was significantly higher at the treprostinil site than at the placebo site and remained higher 30 minutes after the test. Conclusions In patients with SS c, digital treprostinil iontophoresis shifts skin blood flow upward during local cooling of the hand and during the initial rewarming phase. Digital treprostinil iontophoresis should now be tested in larger scale studies.