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Endothelium‐Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions
Author(s) -
Ellinsworth David C.,
Sandow Shaun L.,
Shukla Nilima,
Liu Yanping,
Jeremy Jamie Y.,
Gutterman David D.
Publication year - 2016
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12255
Subject(s) - endothelium derived hyperpolarizing factor , dilator , hyperpolarization (physics) , gap junction , vasodilation , endothelium , microbiology and biotechnology , extracellular , trpv4 , chemistry , intracellular , vascular smooth muscle , medicine , biology , biochemistry , ion channel , smooth muscle , receptor , organic chemistry , nuclear magnetic resonance spectroscopy
Myocardial perfusion and coronary vascular resistance are regulated by signaling metabolites released from the local myocardium that act either directly on the VSMC or indirectly via stimulation of the endothelium. A prominent mechanism of vasodilation is EDH of the arteriolar smooth muscle, with EET s and H 2 O 2 playing important roles in EDH in the coronary microcirculation. In some cases, EET s and H 2 O 2 are released as transferable hyperpolarizing factors ( EDHF s) that act directly on the VSMC s. By contrast, EET s and H 2 O 2 can also promote endothelial K Ca activity secondary to the amplification of extracellular Ca 2+ influx and Ca 2+ mobilization from intracellular stores, respectively. The resulting endothelial hyperpolarization may subsequently conduct to the media via myoendothelial gap junctions or potentially lead to the release of a chemically distinct factor(s). Furthermore, in human isolated coronary arterioles dilator signaling involving EET s and H 2 O 2 may be integrated, being either complimentary or inhibitory depending on the stimulus. With an emphasis on the human coronary microcirculation, this review addresses the diverse and integrated mechanisms by which EET s and H 2 O 2 regulate vessel tone and also examines the hypothesis that myoendothelial microdomain signaling facilitates EDH activity in the human heart.