Premium
Effects of Dietary Supplementation with Brazil Nuts on Microvascular Endothelial Function in Hypertensive and Dyslipidemic Patients: A Randomized Crossover Placebo‐Controlled Trial
Author(s) -
Huguenin Grazielle V.B.,
Moreira Annie S.B.,
Siant'Pierre Tatiana D.,
Gonçalves Rodrigo A.,
Rosa Glorimar,
Oliveira Glaucia M.M.,
Luiz Ronir R.,
Tibirica Eduardo
Publication year - 2015
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12225
Subject(s) - medicine , nitric oxide , crossover study , placebo , endothelial dysfunction , bioavailability , dyslipidemia , vasodilation , endothelium , randomized controlled trial , endocrinology , pharmacology , obesity , alternative medicine , pathology
Objective To investigate the effects of dietary supplementation with GBNs on microvascular endothelial function in hypertensive and dyslipidemic patients. Methods Ninety‐one patients of both sexes aged 62.1 ± 9.3 years received 13 g/day of GBNs or a placebo for three months with a washout period of one month between treatments. Microvascular endothelial function was assessed using LSCI coupled with iontophoresis of ACh and PORH. We also used skin video capillaroscopy to measure capillary density and recruitment at rest and during PORH. Plasma concentrations of NO x were also measured as a marker of nitric oxide bioavailability. Results Supplementation with GBNs significantly increased the plasma levels of Se ( p < 0.05) and NO x ( p < 0.05). However, we did not observe any effects of GBN consumption on microvascular vasodilator responses to ACh or PORH ( p > 0.05), and GBNs did not improve capillary density at baseline or recruitment during PORH ( p > 0.05). Conclusions Supplementation with GBNs induced significant increases in the plasma Se concentration and systemic bioavailability of nitric oxide. Nevertheless, GBN supplementation did not lead to any improvement in systemic microvascular reactivity or density in patients with arterial hypertension and dyslipidemia who were undergoing multiple drug therapies.