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Smooth Muscle Cell Ca 2+ : Think Locally, Act Globally
Author(s) -
Earley Scott
Publication year - 2013
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/micc.12049
Subject(s) - smooth muscle , intracellular , depolarization , myocyte , vascular smooth muscle , calcium signaling , microbiology and biotechnology , cell , neuroscience , cell type , chemistry , biology , biophysics , endocrinology , biochemistry
Dynamic changes in intracellular Ca 2+ levels in vascular smooth muscle cells are critically important for cardiovascular regulation. This Special Topic Issue highlights a series of expert opinion articles focused on this important subject. After a brief overview, novel discoveries surrounding smooth muscle cell Ca 2+ influx via L‐type and T‐type channels are reviewed. Current work revealing the functional importance of dynamic Ca 2+ signaling in the control of the parenchymal microvasculature and the emerging role of mitochondrial Ca 2+ signaling and store‐operated Ca 2+ entry in smooth muscle cells is discussed. Finally, recent data describing a new target of localized Ca 2+ signaling in arterial myocytes that is responsible for membrane depolarization is reviewed. Authors were encouraged to write in an opinionated and provocative manner with the hope of stimulating discussion in this area of research.