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Regulation of transposable elements: Interplay between TE‐encoded regulatory sequences and host‐specific trans‐ acting factors in Drosophila melanogaster
Author(s) -
Jakšić Ana Marija,
Kofler Robert,
Schlötterer Christian
Publication year - 2017
Publication title -
molecular ecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.619
H-Index - 225
eISSN - 1365-294X
pISSN - 0962-1083
DOI - 10.1111/mec.14259
Subject(s) - biology , drosophila melanogaster , transposable element , genetics , gene , melanogaster , dominance (genetics) , regulation of gene expression , regulatory sequence , transcription factor , genome , mobile genetic elements
Transposable elements (TEs) are mobile genetic elements that can move around the genome, and their expression is one precondition for this mobility. Because the insertion of TEs in new genomic positions is largely deleterious, the molecular mechanisms for transcriptional suppression have been extensively studied. In contrast, very little is known about their primary transcriptional regulation. Here, we characterize the expression dynamics of TE families in Drosophila melanogaster across a broad temperature range (13–29°C). In 71% of the expressed TE families, the expression is modulated by temperature. We show that this temperature‐dependent regulation is specific for TE families and strongly affected by the genetic background. We deduce that TEs carry family‐specific regulatory sequences, which are targeted by host‐specific trans‐ acting factors, such as transcription factors. Consistent with the widespread dominant inheritance of gene expression, we also find the prevailing dominance of TE family expression. We conclude that TE family expression across a range of temperatures is regulated by an interaction between TE family‐specific regulatory elements and trans‐ acting factors of the host.