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The rate of adaptive evolution in animal mitochondria
Author(s) -
James Jennifer E.,
Piganeau Gwenael,
EyreWalker Adam
Publication year - 2016
Publication title -
molecular ecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.619
H-Index - 225
eISSN - 1365-294X
pISSN - 0962-1083
DOI - 10.1111/mec.13475
Subject(s) - biology , nonsynonymous substitution , mitochondrial dna , adaptive evolution , evolutionary biology , rate of evolution , molecular evolution , genetics , range (aeronautics) , phylogenetics , mutation rate , synonymous substitution , genome , gene , materials science , composite material , codon usage bias
We have investigated whether there is adaptive evolution in mitochondrial DNA , using an extensive data set containing over 500 animal species from a wide range of taxonomic groups. We apply a variety of McDonald–Kreitman style methods to the data. We find that the evolution of mitochondrial DNA is dominated by slightly deleterious mutations, a finding which is supported by a number of previous studies. However, when we control for the presence of deleterious mutations using a new method, we find that mitochondria undergo a significant amount of adaptive evolution, with an estimated 26% (95% confidence intervals: 5.7–45%) of nonsynonymous substitutions fixed by adaptive evolution. We further find some weak evidence that the rate of adaptive evolution is correlated to synonymous diversity. We interpret this as evidence that at least some adaptive evolution is limited by the supply of mutations.