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Phylodynamics of vampire bat‐transmitted rabies in A rgentina
Author(s) -
Torres C.,
Lema C.,
Dohmen F. Gury,
Beltran F.,
Novaro L.,
Russo S.,
Freire M. C.,
VelascoVilla A.,
Mbayed V. A.,
Cisterna D. M.
Publication year - 2014
Publication title -
molecular ecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.619
H-Index - 225
eISSN - 1365-294X
pISSN - 0962-1083
DOI - 10.1111/mec.12728
Subject(s) - enzootic , biology , desmodus rotundus , epizootic , viral phylodynamics , rabies , vampire , phylogenetic tree , population , rabies virus , ecology , phylogenetics , zoology , evolutionary biology , virology , outbreak , virus , genetics , demography , sociology , gene , computer science , programming language
Common vampire bat populations distributed from M exico to A rgentina are important rabies reservoir hosts in Latin A merica. The aim of this work was to analyse the population structure of the rabies virus ( RABV ) variants associated with vampire bats in the Americas and to study their phylodynamic pattern within A rgentina. The phylogenetic analysis based on all available vampire bat‐related N gene sequences showed both a geographical and a temporal structure. The two largest groups of RABV variants from Argentina were isolated from northwestern Argentina and from the central western zone of northeastern Argentina, corresponding to livestock areas with different climatic, topographic and biogeographical conditions, which determined their dissemination and evolutionary patterns. In addition, multiple introductions of the infection into Argentina, possibly from B razil, were detected. The phylodynamic analysis suggests that RABV transmission dynamics is characterized by initial epizootic waves followed by local enzootic cycles with variable persistence. Anthropogenic interventions in the ecosystem should be assessed taking into account not only the environmental impact but also the potential risk of disease spreading through dissemination of current RABV lineages or the emergence of novel ones associated with vampire bats.