Open AccessEffects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
Author(s) -
Jorgensen Josh M.,
Ashorn Per,
Ashorn Ulla,
Baldiviez Lacey M.,
Gondwe Austrida,
Maleta Ken,
Nkhoma Minyanga,
Dewey Kathryn G.
Publication year - 2018
Publication title -
maternal and child nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 63
eISSN - 1740-8709
pISSN - 1740-8695
DOI - 10.1111/mcn.12640
Subject(s) - medicine , micronutrient , iron deficiency , soluble transferrin receptor , pregnancy , zinc protoporphyrin , ferritin , micronutrient deficiency , anemia , physiology , iron status , biochemistry , chemistry , biology , heme , genetics , pathology , enzyme
We examined the effect of three types of prenatal supplements containing different amounts of iron on haemoglobin (Hb) and iron status (zinc protoporphyrin [ZPP] and soluble transferrin receptor [sTfR]) in late pregnancy among 1,379 women in rural Malawi. Participants were recruited at ≤20 gestational weeks (gw) and randomly assigned to consume daily (1) 60‐mg iron and folic acid (IFA); (2) 20‐mg iron plus 17 micronutrients in a capsule (MMN); or (3) lipid‐based nutrient supplement (LNS; 118 kcal) with 20‐mg iron plus 21 micronutrients, protein, and fat. We analysed differences between intervention groups in mean Hb, ZPP, and sTfR at 36 gw, and the proportion with anaemia (Hb < 100 g L −1 ) and iron deficiency (ZPP > 60 μmol mol −1 haem or sTfR > 6 mg L −1 ) at 36 gw. Women in the IFA group had higher Hb at 36 gw than women in the LNS group ( P = 0.030) and higher iron status (lower ZPP and sTfR) than women in both the LNS ( P < 0.001 for both ZPP and sTfR) and MMN ( P = 0.025 and P = 0.046) groups. Results for anaemia and iron deficiency showed similar trends. Further research is needed to elucidate the appropriate amount of iron to improve Hb and iron status, while improving birth outcomes.