Open AccessVitamin D supplementation is associated with higher serum 25 OHD in A sian and W hite infants living in V ancouver, C anada
Author(s) -
Green Tim J.,
Li Wangyang,
Barr Susan I.,
Jahani Mitra,
Chapman Gwen E.
Publication year - 2015
Publication title -
maternal and child nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 63
eISSN - 1740-8709
pISSN - 1740-8695
DOI - 10.1111/mcn.12008
Subject(s) - medicine , vitamin d and neurology , confidence interval , rickets , vitamin , vitamin d deficiency , logistic regression , pediatrics , physiology
To prevent rickets, the H ealth C anada and the A merican A cademy of P ediatrics recommend that breastfed infants receive a daily vitamin D supplement of 10 μ g d −1 . Compliance with this recommendation is variable and its effect on infant vitamin D status is unclear. We measured serum 25‐hydroxyvitamin D (25 OHD ) in A sian immigrant ( n = 28) and W hite ( n = 37) mothers and their infants aged 2–4 months living in V ancouver (49°N). Mothers completed health and demographic questionnaires. All subjects were term infants who were primarily breastfed. Analysis of variance, χ 2 , multiple regression and logistic regression analysis were performed as appropriate. Mean 25 OHD of the infants was 31 (95% confidence interval 28–34) ng mL −1 . Only two infants had a 25 OHD concentration indicative of deficiency, <10 ng mL −1 . Of the infants, 14% ( n = 9) and 49% ( n = 32) were vitamin D insufficient based on two commonly used cut‐offs of 20 and 30 ng mL −1 , respectively. Fifty‐eight (89%) infants had been given a vitamin D supplement. Mean 25 OHD was 9.4 ng mL −1 higher in infants consuming ≥10 μ g d −1 of vitamin D from supplements vs. those consuming less ( P = 0.003). Mother's 25 OHD , season, skin colour or ethnicity ( A sian vs. W hite) did not influence infant 25 OHD . The infants in our study, most of whom received vitamin D supplements, were generally protected against low 25 OHD . The study was limited by sample size and the nature of the cross‐sectional study design.