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Central obesity indicating a higher prevalence of lower urinary tract symptoms: A case‐control matching analysis from a Chinese cross‐sectional study in males
Author(s) -
Xie Lianguang,
Chen Yang,
Tan Aihua,
Gao Yong,
Yang Xiaobo,
Mo Zengnan,
Zhang Haiying
Publication year - 2019
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/luts.12231
Subject(s) - medicine , lower urinary tract symptoms , odds ratio , confidence interval , obesity , logistic regression , waist , univariate analysis , cross sectional study , waist–hip ratio , international prostate symptom score , demography , multivariate analysis , prostate , pathology , cancer , sociology
Objective The aim of this study was to explore the association between central obesity and lower urinary tract symptoms (LUTS) among men in southern China, and test the hypothesis that central obesity measured by the waist‐to‐hip ratio (WHR) is a predictor of the severity of LUTS. Methods In all, 4303 men from the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) were included in this study. LUTS were assessed by the International Prostate Symptom Score (IPSS), whereas central obesity was evaluated by the WHR. The association between WHR and LUTS was tested using logistic and Cox regression analyses. Results After screening, 2917 participants were in the study. Univariate analysis indicated significant differences in WHR in the presence of LUTS ( P = .012). After stratification by age, logistic regression indicated that LUTS were more frequent in 60‐year‐old men with a higher WHR (odds ratio [OR] 2.89, 95% confidence interval [CI] 1.21–6.89) compared with participants <40 years old. Cox regression analysis after pairing of 252 LUTS cases and 252 control subjects from the 2917 eligible participants according to age (±5 years), indicated that central obesity (WHR ≥0.9) may be significantly associated with moderate or severe LUTS (OR 1.95, 95% CI 1.16–3.26). The associations between central obesity and straining (OR 2.44, 95% CI 1.40–4.24) and weak stream (OR 2.37, 95% CI 1.27–4.45) were significant after multivariate adjustment. Conclusions Males with central obesity are at increased risk of LUTS, and increased WHR is associated with worsened straining and weak stream. Further investigations are needed to confirm these associations.