Premium
Clinical Effects of Formulated Food of P eucedanum japonicum Extract and Saw Palmetto Extract in Male Patients with Lower Urinary Tract Symptoms
Author(s) -
KAGEYAMA Shinji,
BEPPU Masanori,
OHNOGI Hiromu,
MIYAZAKI Sayaka,
HARUNO Akihiro,
ITO Yoshihiko,
YAMADA Shizuo
Publication year - 2018
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/luts.12155
Subject(s) - urination , lower urinary tract symptoms , nocturia , medicine , urinary system , urine , urology , international prostate symptom score , food and drug administration , adverse effect , prostate , pharmacology , cancer
Objectives To evaluate changes over time in subjective symptom scores and urination parameters before and after oral administration of formulated food containing a combination of P eucedanum japonicum ( P . japonicum ) extract and saw palmetto extract ( SPE ) in male patients with lower urinary tract symptoms ( LUTS ). Methods This study was conducted in an open label manner on male patients with untreated LUTS . The urination state of patients was evaluated before and after administration of food formulated with P . japonicum extract and SPE for 4 weeks, based on urodynamic parameters and subjective symptom scores ( I nternational P rostate S ymptom S core [ IPSS and IPSS‐QOL ], O veractive B ladder S ymptom S core [ OABSS ], O veractive B ladder Q uestionnaire [ OAB ‐q], and I nternational I ndex of E rectile F unction [ IIEF ]). Results After the administration of food formulated with these extracts, the following results were obtained: (i) S ubjective findings: T he IPSS‐QOL score improved significantly; both parameters related to nocturia, i.e., frequency of nighttime urination and OABSS ‐2, improved significantly; other ratings for subjective symptoms slightly improved. (ii) Objective findings: R esidual urine volume decreased significantly, and blood prostate specific antigen ( PSA ) and urinary 8‐ OHdG levels decreased slightly after the treatment. (iii) Other findings: B lood pressure decreased slightly. No adverse drug reactions were reported. (iv) Patient impressions: 75% of patients gave a rating of “ G ood” or higher, with 15 out of 20 patients wanting to continue treatment after the end of 4‐week administration period. Conclusions Food formulated with P . japonicum extract and SPE may be useful to decrease frequency of nighttime urination and residual urine volume in male patients with LUTS .