Premium
Serum Testosterone Levels Are Negatively Correlated with International Prostate Symptom Score and Transitional Prostate Volume
Author(s) -
SHIM Ji S.,
KIM Jae H.,
YOON Yong S.,
CHOI Hoon,
PARK Jae Y.,
BAE Jae H.
Publication year - 2018
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/luts.12150
Subject(s) - interquartile range , testosterone (patch) , body mass index , urology , prostate , medicine , lower urinary tract symptoms , international prostate symptom score , endocrinology , cancer
Objectives To investigate the correlation of serum total testosterone levels with I nternational P rostate S ymptom S core and prostate volume in aging men. Methods A cross‐sectional study was conducted in 50 men who had participated in a medical examination. Prostate specific antigen levels, I nternational P rostate S ymptom S core, total/transitional prostate volume, body mass index, maximal flow rate, and serum total testosterone levels were evaluated. The correlation between serum total testosterone levels and additional parameters was statistically analyzed. Results The median age and total testosterone levels were 60.4 years (interquartile range: 55.0–68.0 years) and 4.3 ng/ mL (interquartile range: 3.6–5.1 ng/ mL ), respectively. Total testosterone levels showed a significant negative correlation with body mass index, transitional prostate volume, I nternational P rostate S ymptom S core (including voiding/storage sub scores). On multivariate linear regression models, the total testosterone level was associated with body mass index and total I nternational P rostate S ymptom S core. Conclusions As total testosterone levels decrease, both I nternational P rostate S ymptom S core and transitional prostate volume increase significantly. These findings provide evidence of the presence of more severe lower urinary tract symptoms and larger transitional prostate volume in aging men.