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Impact of Androgen Deprivation Therapy on Volume Reduction and Lower Urinary Tract Symptoms in Patients with Prostate Cancer
Author(s) -
WASHINO Satoshi,
HIRAI Masaru,
SAITO Kimitoshi,
KOBAYASHI Yutaka,
ARAI Yoshiaki,
MIYAGAWA Tomoaki
Publication year - 2018
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/luts.12142
Subject(s) - nocturia , medicine , urology , lower urinary tract symptoms , prostate cancer , international prostate symptom score , androgen deprivation therapy , bicalutamide , prostate , quality of life (healthcare) , goserelin , overactive bladder , urinary system , gynecology , cancer , androgen receptor , alternative medicine , nursing , pathology
Objective To evaluate the impact of androgen deprivation therapy ( ADT ) on prostate volume, lower urinary tract symptoms ( LUTS ), and LUTS ‐related quality of life ( QOL ) in patients with prostate cancer. Methods Patients with prostate cancer ( PCa ) were treated with goserelin and bicalutamide for 24 weeks. Changes in the total prostate volume ( TPV ), International Prostate Symptom Score ( IPSS ), and QOL score for urinary symptoms were assessed every 12 weeks. Of the 42 patients enrolled, 8 patients withdrew and 2 were excluded, so 32 patients were analyzed. Results The median age, PSA levels, and TPV were 77.5 years, 22.0 ng/mL, and 29.5 cm 3 , respectively. TPV showed a significant decrease from baseline in weeks 12 and 24, with the mean percent decreases being −37.5 ± 4.25 and −7.5 ± 3.84%, respectively. The IPSS decreased from baseline to weeks 12 and 24 (from 11.7 ± 1.6 to 9.3 ± 1.0 and 9.3 ± 1.0; P = 0.15 and 0.2, respectively). The IPSS voiding score showed a significant decrease from baseline to weeks 12 and 24 whereas the IPSS storage score did not. In patients with moderate to severe LUTS , the IPSS and the QOL score showed a significant decrease in weeks 12 and 24. In patients with mild LUTS , nocturia increased significantly from baseline and there was approximately one additional episode of nocturia at 24 weeks. Conclusions In this study, we observed that ADT significantly reduced TPV and improved LUTS in patients with PCa and moderate to severe LUTS , but increased nocturia in patients with mild LUTS .