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Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride
Author(s) -
LEE Ha Na,
LEE YoungSuk,
HAN Deok Hyun,
LEE KyuSung
Publication year - 2017
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/luts.12110
Subject(s) - dutasteride , urology , bladder outlet obstruction , medicine , ultrasound , urinary bladder neck obstruction , radiology , prostate , cancer
Objectives To investigate the change of bladder wall hypertrophy to relieve bladder outlet obstruction ( BOO ) by treatment with 5α‐reductase inhibitor. Methods Men who have BOO confirmed by urodynamic study ( BOO index ≥40) were treated with dutasteride 0.5 mg once a day for 6 months. We measured ultrasound estimated bladder weight ( UEBW ), UEBW divided by body surface area ( UEBW / BSA ), and bladder wall thickness ( BWT ) before and after treatment. Changes in LUTS parameters were assessed by using the I nternational P rostate S ymptom S core, uroflowmetry, residual urine volume, prostate volume, serum prostate‐specific antigen ( PSA ), and LUTS outcome scores ( LOS ). Correlation between the change of LUTS parameters and UEBW , UEBW / BSA , and BWT were evaluated. We assessed the changes of bladder wall hypertrophy according to the results of benefit, satisfaction, and willingness to continue ( BSW ) questionnaire. Results Thirty patients completed the 6‐month study. The mean UEBW was 47.10 ± 7.79 g before and 50.07 ± 5.39 g after dutasteride treatment ( P = 0.259). The mean UEBW / BSA was 26.47 ± 4.30 g/m 2 before and 28.2 ± 3.53 g/m 2 after treatment ( P = 0.253), and there was no definite change in mean BWT after treatment ( P = 0.301). Most LUTS parameters including LOS significantly improved. Increased BOO index value was related to decreased BWT (ρ = 0.361, P = 0.049). There was no definite change in mean UEBW , UEBW / BSA , and BWT according to the results of the BSW questionnaire. Conclusions There was no change in UEBW , UEBW / BSA and BWT despite improving most clinical parameters suggesting BOO . The changes of bladder wall hypertrophy parameters still have limitations to directly reflect the relief of BOO .